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Immobilization of membrane proteins from respiratory chain for SEIRAS and SERS studies
University of Strasbourg, Strasbourg
Bioelectrochimie et Spectroscopie, UMR 7140
Physical Chemistry Biophysics 
Full Description:

Thesis in Bioelectrochemistry and Vibrational Spectroscopy Group, University of Strasbourg


We are looking for a highly motivated student to join the ‘bioelectrochemistry and
spectroscopy group’ in the UMR 7140, chimie de la matière complexe (

The project focuses on the study of the reaction mechanism of membrane proteins from the
respiratory chain and the identification of inhibitors by means of electrochemical techniques and vibrational spectroscopies. The biosensor will be created by immobilizing the  proteins
on nanomaterials and the reaction followed by SEIRAS and SERS. We will focus on
cytochrome bd oxidase as privileged enzyme target for future antibacterial drugs and a series of inhibitors tested.  Similarly the NADH:ubiquinone reductase and the ATPase will be investigated. Further experiments will include the  –SCN labeling of these proteins, in order to
monitor redox induced conformational changes on the basis of an infrared probe.

This international project will be part of the binational PhD college “enzyme reactivities and their applications” CDFA 0407 between groups from theuniversity of Strasbourg in France and the university of Freiburg in Germany. Sufficient command of French OR English is requested.  Interested students should have a Master equivalent to the French master with at least 12,5/20 and send us until end of july a short CV, a letter of motivation, the result of the master program and an overview of the teaching program, as well as the name of two referees to


Posted on: 24 July 2015Deadline to apply: 20 August 2015Start Date: 01 October 2015 Duration: 36 months
The Fund category is Public Funding - University and the salary is 20-25k€ annual gross
Doctoral School is Chemical sciences in the Alsace Region.

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