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Super-resolution fluorescence microscopy study of the mechanisms of recognition and repair of UV-induced DNA damage.
UMR5075 - CNRS - CEA - Université de Grenoble, Grenoble
Institut de Biologie Structurale/ Groupe Infection Virale et Cancer
Biology Optical Physics Microbiology 
Full Description:

Damaged DNA generates mutations and genomic instability that ultimately threaten cell or organism viability. Recognition of DNA damage is a very challenging cellular process, which consists in detecting rare modifications to the DNA in a large pool of intact genomic material. The goal of the proposed project is the study of the dynamics of DNA damage localisation, recognition and repair processes in the radiation-resistant bacterium Deinococcus radiodurans. The project will focus on the so-called “nucleotide excision repair pathway”, that is responsible for the removal of a wide variety of structurally
unrelated lesions. The objectives are to investigate the cellular localisation and dynamics of these proteins in vivo using “super-resolution” fluorescence microscopy. In this frame, the so-called
“PALM” super-resolution microscopy technique, based on the detection of single molecules, will be developed so as to carry out quantitative, multi-colour imaging. We expect this work to shed light on the mechanisms used by repair proteins to locate and repair their DNA substrates and, at the same time to contribute to the development of nanoscale fluorescence imaging.

This PhD project is one of the 35 proposed projects offered by the CEA for 2014-2015 as part of the Irtelis PhD programme.

To apply, candidates should follow the instructions found on this page:

Deadline for applying: 27th March 2015

Selected applicants will be interviewed on May 21st.

Candidates interested in this PhD project should contact Joanna Timmins ( before applying.



Posted on: 13 February 2015Deadline to apply: 27 March 2015Start Date: 01 October 2015 Duration: 36 months
The Fund category is CEA and the salary is 20-25k€ annual gross
Doctoral School is Chemistry and life sciences in the Rhône-Alpes Region.

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